From Florence: A1, 'ucita' Val di Chiana, Bettolle, Sinalunga, take the SS.75 Bis direction Perugia and then SS.3 Bis/E45 towards Rome, 'uscita' Torgiano / Bettona.
From Rome: A1 to Florence (Firenze), 'uscita' Orte, take the SS.3 Bis/E45 towards Perugia, 'uscita' Torgiano / Bettona.
From Cesena: SS.3 Bis/E45 direction Perugia/Rome 'uscita' Torgiano / Bettona.
From Bettona
As you approach the city wall of Bettona turn right into Viale Roma putting the walls on your left. At the first junction turn right onto Via Cinque Cerri. After 2,2 km you will see the restaurant Cinque Cerri on your left. After a further 2.3 km turn to the right onto Via San Bernandino (you'll see the sign as soon as you turn; if you see at the left a little Chapel to the Madonna dei Cacciatori you've driven just a tiny bit too far). After a short distance you will see on the left a row of mailboxes next to a gate bearing a sign that says Centro Sant' Antonio Zona Residenziale Privata and with the number 48 on the pillar.Enter this private area. Take the 2nd road on the right (just 25 m. from the gate). You have to follow this road, Via Monte Bandita (0,9 km) till you'll see B&B Le 4 Stagioni at number 9 on your left side (total 5,6 km from Bettona). You can park your car in one of the parking spaces on the left side of the road.

Cars can be rented from all the aiports mentioned as well as from some train stations.
Great experience with Thrifty
Other well known rental companies Avis, Hertz
Timetable: Italy by train
Good connections to Perugia (Ponte San Giovanni) or Assisi.
